"I can’t agree with you." in Spanish

No puedo estar de acuerdo contigo.

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Literal Breakdown

English	Spanish	Learn
not	no	Learn
I can	puedo	Learn
to agree	estar de acuerdo	Learn
with you	contigo	Learn

Summary

The Spanish translation for “I can’t agree with you.” is No puedo estar de acuerdo contigo.. The Spanish, No puedo estar de acuerdo contigo., can be broken down into 4 parts:"not" (no), "I can" (puedo), "to agree" (estar de acuerdo) and "with you" (contigo).